Effects of Natural Beta-carotene and Commercially Available Combination of Beta-carotene, Vitamin E, Vitamin C and Minerals: A Prospective Comparative Study

Abstract

Aim and objective: The purpose of this study was to determine effects of natural beta-carotene and revox in, reducing the oral symptoms of submucous fibrosis patients, thickness of collagen fibers in submucous fibrosis patients and to correlate the changes in epithelium and connective tissue. Materials and methods: The study population consisted of 50 patients with submucous fibrosis divided in two groups randomly. For patents in group A recived intralesional injection of 0.5 ml hyaluronidase 1500 IU and 05 ml hydrocortisone acetate 25 mg/ml were injected in buccal mucosa bilaterally in alternative week and natural beta-carotene capsule twice daily for 12 weeks along with ice cream stick mouth exercise. For group B patients intralesional injections and capsule revox were given twice daily for 12 weeks along with ice cream stick mouth exercise. Results: There is statistical significant improvement in mouth opening, reduction of burning sensation and decrease in thickness of collagen bundles were seen in all patients but there was early response in group A than group B Conclusion: Our preliminary findings suggest that both groups showed statistical significant results with early response in group A. The clinical comparison and effectiveness of natural beta-carotene and revox is not statistical significant.