Effects of muscle contraction on somatosensory event-related EEG power and coherence changes

Abstract

Effects of isometric muscle contraction on amplitude and coherence changes of EEG rhythms during repetitive cutaneous electrical stimulation were analyzed in 10 right-handed subjects. Subjects received electrical stimuli at intensity above pain threshold to their right middle finger while either squeezing a rubber tube with the right index finger and thumb, or keeping their ipsilateral hand muscles relaxed. EEG was recorded using 111 closely spaced electrodes. Somatosensory stimuli were followed by reduction of the relative 8–12 and 16–24 Hz band power (at 0.2–0.4 s) in bilateral primary sensorimotor cortices (S1/M1) and medial frontal cortex, and by a subsequent increase in 16–24 Hz band power (at 0.9 s). Isometric muscle contraction strongly suppressed these band power changes. The 8–12 and 16–24 Hz mean coherence in a wide region surrounding the contralateral S1/M1 and in the medial frontal cortex showed an initial decrease, partially paralleling band power changes, and later an increase. Ipsilateral S1/M1 showed a decrease in 8–12 Hz coupling only with the central and frontal electrodes of the same hemisphere. Muscle contraction reduced all coherence changes, but enhanced the 8–12 Hz coherence between ipsilateral S1/M1 and posterior parietal cortex. Early post-stimulus decrease of oscillatory coupling between S1/M1 and premotor cortex and between S1/M1 and medial frontal cortex suggests that these cortical regions act rather independently during processing of somatosensory information, and synchronize only later when the band power in contralateral S1/M1 increases. Motor cortex activation associated with ipsilateral hand muscle contraction interferes with cortical processing of somatosensory stimuli in S1/M1 cortices.