Abstract
The effects of morphine, adrenaline, and hydrocortisone on uptake of glucose from media of different magnesium content by diaphragm of normal and of chronically morphinized rats have been studied in vitro. The effects of morphine, of adrenaline, and of hydrocortisone on normal diaphragm are each dependent upon the presence in the medium of magnesium within a limited range of concentration. The basic rate of glucose-uptake by chronically morphinized diaphragm, unlike that of normal diaphragm, is not influenced by changes in the magnesium content of the medium and the effect of morphine is not changed by variations in magnesium concentration from 0 to 2.5 mM. Chronically morphinized diaphragm is insensitive to hydrocortisone (3.85 × 10 −6 M) and sensitivity is not restored by changes in magnesium concentration. Chronically morphinized diaphragm is insensitive to adrenaline (3.85 × 10 −6 M) in the standard medium (1.25 mM Mg), but sensitivity is restored by raising the magnesium content of the medium to a level (2.5 mM) which abolishes the effect of the hormone on normal diaphragm.
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