Abstract
The effects of morphine and of hydrocortisone on uptake of glucose from media of different calcium content by diaphragm of normal and of chronically morphinized rats have been studied in vitro. The rate of glucose-uptake by diaphragm from chronically morphinized rats, unlike that by diaphragm of normal rats, is not increased by omission of calcium from a standard medium containing 2.73 mM calcium, but it is depressed by a 2–5 fold increase in the calcium content of the medium. The stimulant effect of added morphine on glucose-uptake by normal rat-diaphragm is dependent upon the presence of calcium in the medium and is much increased by an increase of calcium in the medium. The depressant effect of morphine on glucose-uptake by chronically morphinized rat-diaphragm is but little affected by changes in calcium concentration of the medium from 0 to 5.46 mM. The depressant effect of added hydrocortisone on glucose-uptake by normal rat-diaphragm is unchanged by omission of calcium from the medium, but the stimulant effect on chronically morphinized rat-diaphragm is apparently calcium-dependent.
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