Abstract
Photoinduced hole transfer reaction in DNA duplex bearing cytosine–cytosine (CC) or thymine–thymine (TT) mismatched base pairs as metal-ion binding sites was studied using polyacrylamide gel electrophoresis. Site-specific binding of silver (I) ion to a CC mismatched base pair as well as non-specific binding to multiple sites of nucleobases in the DNA suppressed hole migration through the sequence. In the case of mercury (II) binding to duplex DNA containing single TT mismatch at N3 of the pyrimidine rings, little effect on the efficiency of hole transfer was observed, which is in accordance with a recent theoretical prediction. On the other hand, addition of Hg(II) to duplex containing tandem TT base pairs remarkably reduced hole transfer efficiency, although the calculation has suggested such binding could form high degree of electronic coupling between the hole carrier bases.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
