Abstract
In intact rat hepatoma (HTC) cells, the binding of dexamethasone to the glucocorticoid receptor is inhibited by the calcium ionophore A23187. This effect involves both nuclear-bound and cytoplasmic receptor. Indirect evidence suggests that the inhibition requires intracellular calcium stores. Exposure of the cells to concanavalin A also inhibits dexamethasone binding. Based on earlier work in cell-free systems, it is proposed that membrane-active agents could modulate glucocorticoid hormone action at the receptor level through fluctuations in intracellular free calcium.
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