Abstract
AbstractBackgroundThis study aimed to evaluate the effects of administering flunixin meglumine (FM) and meloxicam (M) on specific days post‐mating on progesterone (P4), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), pregnancy‐specific protein B (PSPB), pregnancy‐associated glycoprotein (PAG) concentrations and fertility parameters in Awassi sheep.MethodsSeventy‐five Awassi sheep were divided into three groups of 25: control, M and FM. On days 9 and 10 post‐mating, the control group received saline, the M group received 0.5 mg/kg M and the FM group received 2.2 mg/kg FM. Blood samples were collected on days 8, 9, 10, 11, 12 and 17 post‐mating.ResultsStatistically significant time‐dependent differences in P4, TAS, TOS, OSI, PSPB and PAG concentrations were found between the groups (p < 0.001). TAS was highest in the M group and lowest in the control group (p < 0.001). TOS was higher in the control group and lower in the M group (p < 0.001). PSPB and PAG were highest in the control group and lowest in the M group (p < 0.05).LimitationFurther studies with larger sample sizes are needed to confirm the findings.ConclusionFM and M significantly affected oxidative stress parameters and early pregnancy factors but not fertility parameters.
Published Version
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