Abstract
The lordosis response in ovariectomized, hormone-primed females was measured in repeated weekly tests before and after bilateral lesions of various medial hypothalamic regions. Changes in body weight, frequency of vaginal marking, and agonistic behavior were also recorded. Forty-two females were divided into five groups based on lesion location: (1) medial preoptic (MPO), (2) medial anterior hypothalamus (MAH), (3) dorsomedial nucleus-dorsal premammillary nucleus (DM-DPM), (4) dorsal ventromedial nucleus (Dorsal VMN), (5) medial basal hypothalamus (MBH). Unoperated control females were tested in an identical manner. Only lesions in the region of the ventromedial nucleus eliminated lordosis. Lesions which disrupted lordosis also increased agonistic behavior in male-female pairs. The frequency of vaginal marking was reduced by lesions in the MPO, MAH, and Dorsal VMN groups. Rapid weight increases and obesity were also seen following certain medial hypothalamic lesions, however no significant correlations were found between degree of weight change and degree of lordosis deficit. A quantitative analysis of VMN damage revealed a relatively low, but statistically significant positive correlation between degree of VMN damage and lordosis deficits. There were no significant correlations between degree of VMN damage and weight change.
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