Abstract
After medial hypothalamic (MH) lesions, rats overeat when given free access to food and undereat when given limited access to food. The present experiments, designed to ascertain the specificity of appetite dysfunctions after MH lesions, indicated: (1) that rats with MH lesions, which do not adjust food intake appropriately during food deprivation, do drink normally when water deprived; (2) that the motivational deficit is apparent in instrumental situations using variable-interval and continuously reinforced schedules of reinforcement; and, (3) that rats with bilateral lateral hypothalamic (LH) lesions respond to food deprivation in a fashion similar to normal rats. These data support the idea that a discrete mechanism which controls the energization of feeding associated instrumental behaviors after food deprivation resides in the medial hypothalamus.
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