Abstract
Previous studies have shown that marine drug propylene glycol alginate sodium sulfate (PSS) plays important roles in human diseases. This study mainly explored the effects of PSS on hyperglycemia and hyperlipidemia in diabetic db/db mouse models. The db/db mice were randomly divided into 5 groups (n=12), which were model control group (distilled water), positive control group (metformin), PSS low, medium, and high dose groups (PSS25, PSS50, PSS100) and normal control group (C57/BL, distilled water). The mice in each group had free diet and water for 90 days. During the experiment, food intake was recorded every day and body weight was recorded weekly. In addition, fasting blood glucose and glycosylated hemoglobin levels were measured regularly. Finally, the contents of triglyceride (TG), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c) and total cholesterol (TC) in the serum of mice were determined. PSS can significantly reduce fasting blood glucose and glycosylated hemoglobin levels in db/db mice, and improve insulin sensitivity. Moreover, PSS can reduce the fat accumulation of db/db mice and significantly improve the blood lipid level of db/db mice. PSS can significantly improve the symptoms of glucose and lipid metabolism disorders in db/db mice.
Highlights
The marine drug propylene glycol alginate sodium sulfate (PSS) is a sulfated polysaccharide compound [1]
The mice in the PSS100 group had the largest weight loss, which was significantly different from the model group (P
The results show that PSS can significantly reduce the weight of mice without affecting their appetite, and has a certain weight loss effect
Summary
The marine drug propylene glycol alginate sodium sulfate (PSS) is a sulfated polysaccharide compound [1]. This experiment uses spontaneous diabetes model mice (db/db) to explore the effect of PSS on diabetes. The increased weight of mice in the model group, PSS group, and positive control group was significantly different from that of the blank group (P
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