Abstract
The effect of feeding 1.6% magnesium oxide (9650 ppm Mg) on the outcome of cataract formation in rats fed a galactose-containing diet was tested. Male, weanling Sprague-Dawley rats were fed diets containing 35% galactose, and were pair-fed to rats eating similar diets but supplemented with magnesium. Galactose-induced cataract formation was significantly accelerated in the magnesium-fed rats. Growth depression was observed in these rats, their plasma magnesium was increased, and their plasma tryptophan decreased. The activity of lens aldose reductase was stimulated by magnesium compounds, in vitro. This suggests that the effect of magnesium in accelerating cataract formation in galactose-fed rats may be related to its effect on aldose reductase activity.
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