Abstract
Glutamate dehydrogenase activity in mitochondrial fraction of the liver and muscle tissue of tumor-bearing rats was studied in the dynamics of Guerin's carcinoma growth and after preliminary low-dose irradiation. At the initial stages of Guerin's carcinoma growth, maximum activity of glutamate dehydrogenase was observed in the liver, while in the muscle tissue, catabolic transformations of amino acids was activated at the logarithmic phase of carcinogenesis and tended to inhibition at the terminal stages. Low-dose irradiation was followed by activation glutamate dehydrogenase in mitochondrial fraction of the liver and inhibition of this enzyme in mitochondrial fraction of the muscle tissue.
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