Effects of low molecular weight heparin sodium and heparin calcium adjuvant therapy on renal function and coagulation function in patients with preeclampsia

Abstract

Objective To analyze the effect of low molecular weight heparin sodium and heparin calcium on renal function and coagulation function in patients with preeclampsia. Methods A total of 208 patients with preeclampsia treated in Maternal and Child Health Hospital of Kaifeng from August 2018 to July 2019 were divided into two groups, with 104 cases in each group. The control group were treated with magnesium sulfate, and the observation group were treated with low molecular weight heparin sodium heparin calcium. Results After treatment, the thrombin time, partially activated prothrombin time in the observation group was significantly higher than those in the control group, and the levels of serum uric acid and urinary protein in the observation group were significantly higher than those in the control group. The levels of D-dimer, high sensitive C-reactive protein in the observation group were significantly lower than those in the control group (P<0.05). The incidence of premature delivery, fetal distress, postpartum hemorrhage and neonatal asphyxia in the observation group were significantly higher than those in the control group (P<0.05). Conclusions Low molecular weight heparin sodium plus heparin calcium can improve the hypercoagulable state of blood, protect renal function and reduce the incidence of adverse pregnancy outcome. Key words: Pregnancy eclampsia; Renal function; Coagulation function; Low molecular weight heparin sodium; Heparin calcium