Effects of α-lipoic acid on oxidative stress markers in type 2 diabetes patients with nonalcoholic fatty liver disease

Abstract

Objective To study the serum levels of oxidative stress markers in the new type 2 diabetes mellitus(T2DM) patients with nonalcoholic fatty liver disease(NAFLD), and the effect of α-lipoic acid(A-LA) on oxidative stress markers. Methods From August 2016 to August 2017, 80 new T2DM patients complicated with NAFLD (T2DM + NAFLD group) and 80 new T2DM patients without NAFLD (T2DM group) admitted to Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University were selected.The serum levels of Fasting blood glucose(FPG), body mass index(BMI), triglyceride(TG), total cholesterol(TC), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), insulin resistance index(HOMA-IR), serum superoxide dismutase(SOD), serum malondialdehyde(MDA), glutathione peroxidase(GSH-PX) were detected and compared between the two groups.And then, the T2DM patients with NAFLD were treated by A-LA for two weeks.The SOD, MDA, GSH-PX levels were compared before and after treatment. Results The FPG, BMI, TG, HOMA-IR of the T2DM+ NAFLD group were (10.71±3.63)mmol/L, (27.08±3.87)kg/m2, (3.40±1.85)mmol/L, (5.40±2.98), respectively, which were significantly higher than those of the T2DM group[(9.50±3.78)mmol/L, (23.58±2.75)kg/m2, (1.79±1.44)mmol/L, (2.41±1.18)](t=2.022, 6.603, 2.829, 4.157, all P 0.05). The level of MDA in the T2DM+ NAFLD group was (5.11±0.25)μmol/L, which was significantly higher than (4.56±0.28)μmol/L in the T2DM group(t=2.106, P<0.05). The levels of SOD, GSH-PX, SOD/MDA in the T2DM+ NAFLD group were (77.42±10.31)U/mL, (69.62±9.24)U, (15.39±2.23), respectively, which were significantly lower than those in the T2DM group[(93.26±11.21)U/mL, (87.54±9.58)U, (20.33±2.93)](t=2.455, 2.653, 3.148, all P<0.05). After treatment with A-LA, the MDA level of the T2DM+ NAFLD group was (4.81±0.26)μmol/L, which was significantly lower than that before treatment[(5.11±0.25)μmol/L, t=2.117, P<0.05], the levels of SOD, GSH-PX, SOD/MDA of the T2DM+ NAFLD group were (87.15±10.88)U/mL, (78.73±9.57)U, (18.05±2.51), respectively, which were significantly higher than those before treatment(t=2.117, 2.207, 2.228, 3.148, all P<0.05). Conclusion A-LA might prove usefully in the treatment of patients with T2DM and NAFLD by change the oxidative stress. Key words: Diabetes mellitus, Type 2; Fatty liver; Oxidative stress; Thioctic acid