Abstract
Objective To investigate the effects of metoprolol combined with levocarnitine on cardiac function and serum transforming growth factor-β1 (TGF-β1) and soluble intercellular adhesion molecule-1 (sICAM-1) levels in patients with chronic heart failure (CHF). Methods Ninety-three patients with CHF were randomly divided into two groups: control group (n=46) and study group (n=47), the control group was treated with metoprolol, and the study group was treated with metoprolol and levocaine, the two groups were treated for 28 d. The cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), Left ventricular end-systolic volume (LVSDV), left ventricular end-diastolic diameter (LVEDD)], serum TGF-β1, sICAM-1 levels and quality of life scores were compared between the two groups before and after treatment, and the clinical outcomes and the incidences of adverse reactions were compared. Results There were no significant differences in LVEF, LVESD, LVEDD and LVSDV between the two groups before treatment (P>0.05); after treatment, compared with the control group, the LVESD, LVEDD and LVSDV levels in the study group were significantly lower and LVEF level was significantly higher (P 0.05), after treatment, the serum TGF-β1 and sICAM-1 levels in the study group were significantly lower than those in the control group (P 0.05). There was no significant difference in the physical function, physiological function, sleep quality, vitality or other life quality scores between the two groups before treatment, while after treatment, those indeces in the study group were significantly higher than those in the control group (P<0.05). Conclusions Metoprolol and levocarnitine combined treatment has significant effect on CHF patients, with can effectively improve the cardiac function and serum TGF- β1, sICAM-1 level, and improve the quality of life of patients, and has higher security. Key words: Metoprolol; Levocarnitine; Chronic heart failure; Cardiac function; Transforming growth factor-β1; Soluble intercellular adhesion molecule-1
Published Version
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