Year-end Sale % OFF 
Abstract
We studied the effects of antagonists of arachidonic acid metabolism and calcium entry on the responsiveness of airway smooth muscle to acetylcholine (ACh), potassium and norepinephrine.Responsiveness in vitro was assessed by measuring isometric contraction of guinea pig trachealis muscle upon chemical stimulation. We found that indomethacin potentiated the response of airway muscle to ACh and KCl, but not to norepinephrine. The indomethacin-induced potentiation observed was inhibited by both BW 755C and nifedipine. As occurred with indomethacin pretreatment, we also found that a noncontractile concentration of leukotriene D4 (LTD4) potentiated the responsiveness of tracheal muscle to both ACh and KCl. Our data suggest that indomethacin- and LTD4-potentiation of guinea pig airway muscle responsiveness to certain bronchoconstrictors may be mediated, at least in part, by enhanced extracellular Ca++ entry.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
