Abstract
The effects of leukemia inhibitory factor (LIF) on the differentiation and proliferation of astrocyte progenitor cells in an enriched culture were studied. The astrocyte progenitor cells obtained from embryonic mouse cerebral hemispheres were enriched by subculturing twice in serum-free medium containing epidermal growth factor (EGF). They exhibited a flat, non-process-bearing morphology and were negative for glial fibrillary acidic protein (GFAP), a specific marker for astrocytes. Culture of the cells with LIF resulted in the expression of GFAP and in the inhibition of growth. These results suggest that LIF promotes the differentiation of astrocyte progenitor cells.
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