Abstract
BackgroundLaunaea procumbens is used in the treatment of oxidative stress and mental disorders. The effects of Launaea procumbens methanolic extracts (LPMEs), i.e., 100 and 200 LPME mg/kg body weight (b.w.), on cognitive performance as well as on the activity of acetylcholinesterase, and antioxidant enzymes in rat brain tissue homogenates were evaluated.MethodsThirty male Sprague–Dawley rats were divided equally into three groups. Rats in group I (control) were given saline (vehicle), group II received LPME (100 mg/kg b.w., p.o.), and group III were treated with LPME (200 mg/kg b.w., p.o.) in dimethyl sulfoxide (DMSO) for 7 days. Antioxidant potential was assessed by measuring the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHpx), glutathione reductase (GSR) and glutathione-S-transferase (GST) as well as lipid peroxidation and glutathione (GSH) contents in brain tissue homogenates. Activity of acetylcholinesterase (AChE) and cognitive performance were also assessed.ResultsLPME administration reduced the levels of lipid peroxidation products (TBARS contents), increased GSH levels and enhanced the activities of SOD, CAT, GSHpx, GSR and GST. AChE activity was reduced by LPME treatment compared with untreated controls.ConclusionThese findings suggested the significant impact of LPMEs on brain function. These effects could be through the antioxidant effects of the bioactive constituents present in LPME.
Highlights
Launaea procumbens is used in the treatment of oxidative stress and mental disorders
Effect of Launaea procumbens methanolic extracts (LPMEs) on the step-through test learning ability Behavioral changes in rats were measured with the administration of LPME (Table 1)
LPME markedly increased (p = 0.05) step-through latency (STL) compared with the untreated control
Summary
Launaea procumbens is used in the treatment of oxidative stress and mental disorders. The effects of Launaea procumbens methanolic extracts (LPMEs), i.e., 100 and 200 LPME mg/kg body weight (b.w.), on cognitive performance as well as on the activity of acetylcholinesterase, and antioxidant enzymes in rat brain tissue homogenates were evaluated. Herbs possess bioactive constituents such as polyphenolic compounds which regulate the defense system of the plant against oxidative insult. Launaea procumbens (LP) is a plant used in the treatment of rheumatism, inflammation and oxidative dysfunction in the kidney [2], reproductive disorders [3], hormonal imbalances [4] and liver dysfunction [5]. The present study was designed to investigate the effect of administration of Launaea procumbens in rats on cognitive performance as well as the activity of acetylcholinesterase, and antioxidant enzymes in rat brain tissue homogenates
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