Effects of laparoscopic radical resection of colorectal cancer on coagulation function and serum levels of ET and CRP in patients with colorectal cancer

Abstract

Objective To explore the effects of laparoscopic radical resection of colorectal cancer on coagulation function and serum levels of ET and CRP in patients with colorectal cancer. Methods The clinical data of 82 patients with colorectal cancer treated at our hospital from January, 2018 to January, 2019 were retrospectively collected. According to the treatment methods, they were divided into a control group and an observation group, with 41 cases in each group. The control group were treated by laparotomy, and the observation group by laparoscopic radical resection. The coagulation function and serum levels of ET and CRP, as well as the incidence of complications, were compared between these two groups. Results After the operation, The PT, APTT, ET level, and CRP level were (11.65±0.82) s, (26.98±1.72) s, (55.17±8.29) pg/ml, (36.52±3.63) mg/L in the observation group, and were (12.03±0.38) s, (29.60±1.81) s, (60.84±8.72) pg/ml, and (48.18±6.79) mg/L in the observation group, with statistical differences (all P<0.05). The short-term incidence of complications, the distant metastasis rate, and the local recurrence rate were lower in the observation group than in the control group (2.44% vs. 19.51%, 4.88% vs. 21.95%, and 2.44% vs. 19.51%; all P<0.05). Conclusion Laparoscopic radical resection for patients with colorectal cancer is easy to affect coagulation function, but has little effect on serum levels of ET and CRP, cause few complications, and is beneficial to the patients’ outcomes. Key words: Colorectal cancer; Laparoscopic radical resection of colorectal cancer; Coagulation function