Abstract
Introduction: Burn is among the traumas that impose great physical and psychological damages to the injured people. Scientists still are looking for new treatments and methods for burn management that lack the defects of previous ones. Recently, the potential of probiotic bacteria for the treatment of skin disease and problems has been investigated. Considering that the effects of probiotics are strain-dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Materials and methods: After induction of second-degree burn wounds on the back of rats, they were randomly divided into experimental, vehicle control, and negative control groups. The experimental groups received a bacterial ointment for 1, 3, 7, and 14 days. The vehicle control groups received Eucerin for durations like the experimental groups. The negative control groups received no treatment in the same days. The evaluation of wound healing was conducted macroscopically by computing of the healing percent and microscopically by Hematoxylin and Eosin staining of the tissue samples of the wound area on different days. Results: The wound healing percent in the experimental group, compared with control groups, significantly increased, until the day 7 of the experiments. Moreover, the microscopic results indicate that the bacteria may have some anti-inflammatory effects. Also, the bacteria increased the rate of fibroblastic migration and re-epithelialization in the wound area.
Highlights
Burn is among the traumas that impose great physical and psychological damages to the injured people
In all experimental, vehicle control and negative control gropes, in the day 3 of the experiments, there was an increase in the wound area compared to the first day of the experiments, in other words, the percent of wound healing was negative in all groups
The results of the current study showed that L. rhamnosus (ATCC 7469) may accelerate the healing process of burn wound healing at least in middle phases of the process
Summary
Burn is among the traumas that impose great physical and psychological damages to the injured people. Considering that the effects of probiotics are strain-dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Previous studies on the effects of topical treatment of wounds with some strains of lactic acid bacteria on the healing process have shown some promising results [8,9,10,11]. Considering the above and because of specificity of probiotics effects that depend on species or even the strains that are used [6, 7], the aim of current study was to evaluate the topical application of L. rhamnosus (ATCC 7469) on the healing of second-degree burn wound in male Wistar rats
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