Abstract
A newly found strain, Lactobacillus plantarum CQPC01 (LP‐CQPC01), was used for soybean milk fermentation, and its effects against constipation were determined. LP‐CQPC01‐FSM (LP‐CQPC01‐fermented soybean milk) was found to have six kinds of soybean isoflavones; the isoflavones of LP‐CQPC01‐FSM were more than those of Lactobacillus bulgaricus‐fermented soybean milk (LB‐FSM) and unfermented soybean milk (U‐FSM). Animal experiment showed that the MTL, Gas, ET, AchE, SP, VIP, and GSH levels in the constipated mice were increased; however, the SS, MPO, NO, and MDA levels in the constipated mice were reduced by soybean milk treatment. Further, LP‐CQPC01‐FSM increased the mRNA and protein expression of Cu/Zn‐SOD, Mn‐SOD, CAT, c‐Kit, SCF, and GDNF and reduced the expression of TRPV1 and NOS relative to those of the mice with untreated constipation. LP‐CQPC01 could be used as a new starter to produce high‐quality soybean milk, which might be used as a functional drink.
Highlights
There are a large number of lactic acid bacteria in pickled cabbage, and some of these strains have probiotic potential
L. bulgaricus (LB)‐FSM group: mice treated with Lactobacillus bulgaricus‐fermented soybean milk; LP‐CQPC01‐FSM group: mice treated with Lactobacillus plantarum CQPC01‐fermented soybean milk; U‐FSM group: mice treated with unfermented soybean milk
These results suggest that LP‐CQPC01‐FSM exhibits the highest increases in GI transit ability, followed by LB‐FSM and U‐FSM after constipation is induced
Summary
There are a large number of lactic acid bacteria in pickled cabbage, and some of these strains have probiotic potential. Oxygen free radicals and lipid peroxidation play an important role in the metabolism of the human body. The antioxidative substances obtained by multiple extraction methods will increase the probiotics in the intestinal tract and benefit the health of the human body, including the inhibition of constipation, inflammation, and even cancer (Hochstein & Atallah, 1988; Jabri et al, 2017; Valtueña et al, 2008; Venturi et al, 2017). The phenolic hydroxyl group acts as an oxygen donor to react with free radicals in order to produce corresponding ions or molecules, extinguishing radicals and terminating the chain reaction of free radicals (Zuo et al, 2011) Both genistein and daidzein are active substances exhibiting improved antioxidant activity. Comparison with the commercial strain L. bulgaricus‐fermented soybean milk (LB‐FSM) as a control was conducted to verify the effects of LP‐CQPC01‐FSM and determine the mechanism underlying the inhibitory action on constipation through its antioxidative effects
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