Abstract
Hypophysectomized rats which received a cholesterol-free diet containing 10 % fat maintained somewhat higher hepatic concentrations of cholesterol, phospholipides and total fatty acids and slightly higher concentrations of cholesterol in plasma than normal rats previously studied. On the same diet, hypophysectomized rats which received excessive L-thyroxine maintained similar hepatic concentrations of phospholipides and total fatty acids; however, the concentrations of cholesterol were higher in liver and lower in plasma. The thyroxine-induced increase in hepatic cholesterol occurred in the nonesterified fraction. After the intraperitoneal injection of sodium l-C14-acetate, more carbon 14 was recovered in the digitonin-precipitable sterols, fatty acids and phospholipides from livers of the thyroxine-treated rats than in these substances from the livers of rats in the untreated group.
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