Abstract
Effects of L-glutamic acid and pyridoxine on glutathione depletion and lipid peroxidation generated by epinephrine-induced stress in rats
Highlights
Oxidative stress – an imbalance in prooxidant/antioxidant homeostasis has been implicated in response to acute stress or other factors and associated with the initiation and progression of a variety of human diseases [1,2,3,4]
During the stress conditions and diseases the organism requires the large number of L-Glu, which plays a major role in nitrogen metabolism, participates in protein and carbohydrate metabolism, stimulates oxidative processes, increases the body's resistance to hypoxia, normalizes metabolism and manifests hepatoprotective effect [10,11,12]
The GSH content in rats of the first experimental group which received only epinephrine was lower in the spleen tissues 1.7 times, in the liver – 1.9 times, in the brain – 4.3 times, in the lungs – 3.3 times, in the myocardium almost 2.5 times compared to control animals
Summary
Oxidative stress – an imbalance in prooxidant/antioxidant homeostasis has been implicated in response to acute stress or other factors and associated with the initiation and progression of a variety of human diseases [1,2,3,4]. During the stress conditions and diseases the organism requires the large number of L-Glu, which plays a major role in nitrogen metabolism, participates in protein and carbohydrate metabolism, stimulates oxidative processes, increases the body's resistance to hypoxia, normalizes metabolism and manifests hepatoprotective effect [10,11,12]. Choosing this amino acid we are guided by that fact that LGlu is a part of GSH and is one of the main factors that determines its synthesis. With regard to the above, the aim of our study was to investigate and compare the effect of L-Glu and L-Glu in combination with Pyridoxine on the glutathione system indicators and the content of lipid peroxidation products in rats under the action of experimental stress
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