Abstract
Objective To explore the effects of Jinyaodai on neurological behavior and Akt expression in the cortex of rats following spinal cord contusion injury. Methods Rats were randomly divided into control group, spinal cord contusion group and Jinyaodai group. The weight-drop device was employed to prepare the spinal cord injury(SCI) model. Jinyaodai was administrated every day by using a stomach tube. Rats were performed the BBB assessment, and the detection of Akt expression and count of Neun positive neurons in cortex following SCI. Results Compared with control group, deficit of motor function in hindlimbs was seen at 3 dpo following cord contusion, and partial functional recovery could be seen from 7 dpo to 1m. Treatment of Jinyaodai greatly increased the BBB scores (14.1±1.4) more than SCI group (7.8±1.3) at 1 month(P<0.05); Simultaneously, compared with SCI rats, treatment of Jinyaodai significantly increased the expression of Akt(0.53±0.05, 0.68±0.07, P<0.05)and the number of neurons(11±2, 15±1; P<0.05)in the lesion-induced cortex of rats. Conclusion Jinyaodai may play an essential roles in functional recovery after spinal cord injury, in which the underlying mechanism may be involved in the expression of Akt in cortex. Key words: Jinyaodai; Contusion spinal cord injury; Hindlimb motor function; Protein kinase B
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