Abstract
Background & Aims: To clarify the effects of treatment with inositol’s, D-chiro-inositol, myo-inositol, and pinitol, on hormonal and metabolic parameters in women with Polycystic Ovary Syndrome (PCOS), we conducted a systematic review and meta-analysis of recent randomized clinical trials of inositol’s in PCOS. Methods: The systematic review was conducted using data obtained from randomized controlled trials performed to assess the effects of inositol’s compared with placebo (UMIN000025843). The primary outcomes included serum insulin, HOMA index, sex hormones, and ovulation rate. Results: Eight studies involving 577 patients were eligible for systematic review. The meta-analysis results showed that compared with the control group, inositol’s may improve fasting insulin (Standardized Mean Difference (SMD) −1.06, 95% CI −1.83 to −0.29, p = 0.007), area under the curve (AUC) of Oral Glucose Tolerance Test (insulin SMD −0.76, 95% CI −1.20 to −0.32, p = 0.0008; glucose SMD −0.55, 95% CI −0.88 to −0.17, p = 0.004), free testosterone (SMD −1.94, 95% CI −3.28 to −0.61, p = 0.004), sex hormone binding globulin (SMD 1.10, 95% CI 0.37 to 1.82, p = 0.004), and ovulation rate (Risk Ratio 1.42, 95% CI −1.00 to 2.02, p = 0.05). Conclusions: Inositols may be effective for PCOS by improving insulin resistance. Keywords: Inositol, Polycystic ovary syndrome, Systematic review, Meta-analysis
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