Abstract
Stress- and virus-induced immunosuppression are considered major risk factors for the development of bovine respiratory disease (BRD) in beef calves. Although vaccines and the metaphylactic use of antibiotics are available to minimize BRD in herds, it continues to be the leading cause of morbidity in feedlot calves. Research in mice found that lethal bacterial pneumonia was prevented by stimulating the innate immune system. The purpose of this study was to determine if stimulation of innate immune responses on arrival to a feedlot could decrease the prevalence and severity of naturally occurring BRD in beef calves.
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