Effects of inhalation and intravenous anesthesia with sevoflurane versus total intravenous anesthesia on recovery of patients undergoing partial hepatic resection

Abstract

Objective To investigate the effects of inhalation and intravenous anesthesia with sevoflurane versus total intravenous anesthesia on recovery of patients undergoing partial hepatic resection. Methods Fifty ASA I or Ⅱ patients undergoing partial hepatic resection were allocated randomly into two group A and group B. After induction, general anesthesia was maintained with sevoflurane (0.3~0.5 MAC), propofol (1.5~3.0 μg/ml target plasma concentration) and remifentanil (2.0~8.0 ng/ml target plasma concentration) in group A and propofol (3.0~6.0 μg/ml target plasma concentration), remifentanil (2.0~8.0 ng/ml target plasma concentration) in group B. The times for respiration recovery, awakening, and extubation, as well as bucking response, were recorded. The Sedation-Agitation Scale and pain score were also noted 1 (T1), 5 (T2), 10 (T3), 20 (T4), 30 (T5), and 40 min (T6) after extubation. Results The times for respiration recovery, awakening, and extubation in group A were shorter than those in group B [(8.0±3.5) mim vs. (15.0±5.2) min, (13.0±4.8) min vs. (20.6±6.0) min, and (14.7±5.1) mim vs. (22.4±7.1) min; all P<0.05]. The incidence of bucking response was higher in group A than in group B (60.0% vs. 20.0%, P<0.05). Conclusion Inhalation and intravenous anesthesia with sevoflurane can decrease the times of respiration recovery, extubating, and awakening; and total intravenous anesthesia can lower the incidence of bucking response in patients with partial hepatic resection. Key words: Sevoflurane; Inhalation and intravenous anesthesia; Total intravenous anesthesia; Hepatic resection