Effect of different methods of anesthesia on hepato-renal function in patients with diabetes and liver cancer after hepatectomy

Abstract

Objective To investigate the effect of using total intravenous anesthesia with propofol and intravenous- inhalation anesthesia with sevoflurane on hepato- renal function in patients with liver cancer and diabetes after hepatectomy. Methods Seventy-four patients with primary liver cancer and diabetes, who were hospitalized in the Department of Hepatobiliary Surgery, the First Affiliated Hospital of PLA General Hospital between June 2012 and June 2015, were included as the subjects in the study. All the patients were divided into the propofol group (n=37) and sevoflurane group (n=37) by random digit method, and underwent hepatectomy by using total intravenous anesthesia with propofol and intravenous - inhalation anesthesia with sevoflurane, respectively. The indicators of hepato - renal function in the two groups were determined before and after operation. Results At 24 h and 72 h after operation, the serum cystatin C and 24 h urine protein quantitation were significantly increased as compared with those before anesthesia induction in the two groups (all P 0.05). The serum ALT, AST, LDH and ALP levels at 3 days after the operation were significantly increased as compared with those before the anesthesia induction in the two groups (all P<0.05). The serum LDH and ALP levels in the sevoflurane group were significantly lower than those in the propofol group at 3 days after the operation (both P<0.05). Conclusion Intravenous - inhalation anesthesia with sevoflurane has less effect on hepato-renal function in patients with liver cancer and diabetes during hepatectomy. Key words: Propofol; Sevoflurane; Liver neoplasms; Diabetes mellitus; Hepatectomy