Abstract
We investigated the effect of indomethacin (INDO) and hyperventilation (HV) on cerebral hemodynamics and oxygenation in newborn piglets using near-infrared spectroscopy (NIRS). A total of 10 piglets aged 7-10 days were divided into 2 groups. INDO (Experimental group; 0.2 mg/kg i.v.) or saline (Control group) was administered after steady state, then each group was hyperventilated (pCO2; 20 mm Hg). Cerebral oxyhemoglobin concentrations (HbO2) significantly decreased immediately after INDO administration compared to controls (p < 0.01). This decrease continued for 15 min. During HV, HbO2 remained low compared to the steady state (p < 0.05) in the experimental group. Total hemoglobin concentrations (HbT) decreased simultaneously with HbO2. In the control group, no changes in HbO2 or HbT were observed after saline administration, and only a slight decrease in HbO2 was observed during the 5 minutes' HV compared to the steady state. No changes in cytochrome aa3 (Cytaa3) were observed in either group during 100% O2 inhalation. We conclude that INDO decreased HbO2 and HbT by vasoconstriction, but that HV did not further aggravate this tendency. Great care should be taken when using INDO for newborn neonates.
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