Sleep state changes associated with cerebral blood volume changes in healthy term newborn infants.

Abstract

In order to assess the possible effects of sleep states on cerebral haemodynamics in healthy term infants, we measured cerebral oxyhaemoglobin, deoxyhaemoglobin and total haemoglobin concentration using near infrared spectroscopy. Thirty-seven sleep state changes in seventeen infants (gestational age: 37 to 41 4/7 weeks), aged between two and eight days were continuously registrated during 1-3 h. Transcutaneous PaO2, PaCO2, arterial O2 saturation and heart rate were simultaneously recorded and sleep states were clinically defined. There was a close relationship between sleep state changes and changes in total cerebral haemoglobin concentration, which increased from active to quiet sleep and decreased from quiet to active sleep. Changes in total cerebral haemoglobin were due, in the most part, to changes in the cerebral oxyhaemoglobin concentration. In conclusion, sleep states influence the cerebral haemoglobin concentration. Studies on cerebral haemodynamics should take sleep state into account in term newborn infants.