Abstract
To determine whether the biological activity of lutein and 8-methoxypsoralen are related to their effect on membrane lipids, their effects, in the dark, on liposomal and erythrocyte membranes were studied by electron paramagnetic resonance (by use of a spin label), by ultrasound absorption, and by differential scanning calorimetry. Incorporation of lutein or 8-methoxypsoralen into erythrocyte membranes increased the fluidity of the membrane in the lipid core adjacent to the hydrophilic zone (as monitored with 5-doxyl-stearic acid spin label). Both compounds also increased ultrasound absorption in dipalmitoylphosphatidylcholine liposomes and reduced the temperature of the main phase transition. These results indicate that despite their different chemical structures and their different localization in the membrane, on a molecular level the mode of action of these two drugs on biomembranes is very similar.
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