Abstract
The effects of 2.5 mg/kg.day ibudilast, with or without 300 mg/kg.day nicomol, or 10 mg/kg.day ibudilast on calcium and magnesium concentrations in the central nervous system (CNS), heart, liver, kidney, skeletal muscle, abdominal aorta and bone were determined in rabbits fed a 1% cholesterol-rich diet for 3 months. Serum thromboxane B2 concentrations were reduced in rabbits treated with 10 mg/kg.day ibudilast or with 2.5 mg/kg.day ibudilast plus 300 mg/kg.day nicomol, and atherosclerotic lesions were ameliorated compared with untreated rabbits. Calcium concentrations in the frontal cortex and cerebellum were lower in ibudilast/nicomol-treated rabbits and in those fed a standard diet compared with those receiving a cholesterol-rich diet only. Calcium concentrations in the pons and abdominal aorta were also lower in ibudilast/nicomol-treated rabbits whereas the calcium concentrations in the cerebellum were lower in rabbits treated with either 2.5 or 20 mg/kg.day ibudilast. There were no significant changes in tissue magnesium concentrations after feeding a cholesterol-rich diet, with or without drug treatment. It is concluded that 2.5 mg/kg.day ibudilast plus 300 mg/kg.day nicomol or 10 mg/kg.day ibudilast produced a scavenger effect on calcium deposited in the CNS and abdominal aorta of rabbits fed a cholesterol-rich diet.
Published Version
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