Abstract
The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D). 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise. T1D patients' glycaemia decreased in response to ExC (p<0.01) and ExInt (p<0.05) under hypoxic conditions. ExInt in normoxia (p<0.05) and hypoxia (p<0.05) reduced HIF-1α in the T1D group. A tendency for vascular endothelial growth factor to increase after ExInt in hypoxia (6.0±3.8 vs. 17.1±13.07 pg/mL) and a proinflammatory cytokine TNF-α level to decrease (33.2±19.1 vs. 25.1±14.4 pg/mL) was found in the same group. Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.
Published Version
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