Abstract
Effects exerted by localized hypothalamic and hypophysial implants of minute amounts of estradiol benzoate on pituitary and plasma LH were studied with the use of the ovarian ascorbic acid depletion method (OAAD). In control ovariectomized rabbits the pituitary LH content measured 0.53 ±0.05 μg/mg- When estrogen was implanted in the posterior median eminencebasal tuberal region of the hypothalamus (PME), the pituitary LH content was reduced to less than 0.1 μg/mg in 5 of 7 rabbits. However, when estrogen was implanted in other parts of the hypothalamus, it failed to depress pituitary LH (0.51 ±0.06 μg/mg). With estrogen in the anterior hypophysis, the pituitary LH content was also somewhat lowered (0.34 ±0.03 μg/mg). The castration level of plasma OAAD, an indicator of plasma LH content, was 21.6 ± 3.3 % as compared with the normal (noncastrate) level of 5.8 ±0.9%. Estrogen implants in PME inhibited the postcastration elevation in plasma OAAD (9.1 ±3.4%), whereas implants in other parts of the hypothalamu...
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