Abstract
Hypophysectomized made red-spotted newts exhibited hyponatremia but not hypocalcemia. Parathyroidectomy and a combination of hypophysectomy and parathyroidectomy caused plasma calcium levels to fall, but control levels were reestablished within 12 days. Injections of ovine prolactin had no effect on the plasma calcium or sodium levels of sham-operated and parathyroidectomized newts conditioned in tap water or in a 0.6% sodium chloride solution containing 10 meq calcium/liter. These data indicate that the pituitary gland is not involved in the hypercalcemic regulation of the red-spotted newt.
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