Effects of hyperbaric oxygen combined with Naoxintong capsules on serum BDNF, TGF-β1 and endothelial function in the patients with hypertensive intracerebral hemorrhage

Abstract

Objective To investigate the effects of hyperbaric oxygen (HBO) combined with Naoxintong capsules on serum BDNF, TGF-beta 1 and endothelial function of the patients with hypertensive intracerebral hemorrhage. Methods Eighty patients with hypertensive intracerebral hemorrhage who were hospitalized from November 2016 to November 2018 were randomly divided into the observation group and the control group, each consisting of 40 patients. The control group took Naoxintong capsules 3 times a day, while the treatment group was supplemented with HBO therapy in addition to the treatment received by the control group. The clinical efficacy, NIHSS scores, Barthel indexes, endothelial function and serum levels of brain-derived neurotrophic factor (BDNF) and changes in the levels of TGF-beta 1 were closely observed. Results After 3 courses of treatment, the total effective rate of the observation group (90.0%) was obviously higher than that (72.5%) of the control group (P<0.05). Following treatment, the NIHSS scores of the 2 groups were all lower than those before treatment, and the scores of the observation group after treatment were lower than those of the control group after treatment (P<0.05 or P<0.01). The BI scores of the 2 groups after treatment all elevated, as compared with those before treatment, and the scores of the observation group after treatment were higher than those of the control group after treatment (P<0.05 or P<0.01). The NO levels of the 2 groups after treatment all increased prominently as compared with those before treatment, and the NO level of the observation group after treatment were higher than those of the control group after treatment (P<0.05 or P<0.01). The ET-1 levels of the 2 groups after treatment all decreased considerably as compared with those before treatment, and the ET-1 level of the observation group after treatment was lower than that of the control group after treatment (P<0.05 or P<0.01). As compared with those before treatment, the BDNF and TGF-β-1 levels of the 2 groups after treatment all elevated markedly, and those of the observation group after treatment were higher than those of the control group after treatment (P<0.05 or P<0.01). Conclusion Through the regulation of serum BDNF and TGF-β1 levels and the decrease of inflammatory response, HBO combined with Naoxintong capsules could improve neuroendothelial function in the patients with hypertensive intracerebral hemorrhage, with sound clinical efficacy and good safety. For this reason, it was worth further clinical promotion. Key words: Hyperbaric oxygen; Naoxintong capsule; Cerebral hemorrhage; Brain-derived neurotrophic factor; Transforming growth factor β1