Clinical study on the treatment of hypertensive cerebral hemorrhage with hyperbaric oxygen combined with minimally invasive catheter puncture

Abstract

Objective To observe the effects of hyperbaric oxygen (HBO) combined with minimally invasive catheter puncture in the treatment of hypertensive intracerebral hemorrhage (HICH). Methods One hundred and twenty-two cases of HICH were divided into the observation group (63 cases) and the control group (59 cases), in accordance with treatment methods. The control group received Edaravone injection and ganglioside injection, in addition to routine therapy, while the observation group received the same treatment as the control group plus HBO. Then, changes in the levels of intracranial pressure (ICP), mean arterial pressure (MAP) , neurological deficit (NIHSS) scores, daily life ability scale (ADL) classification, stroke scale scores (SSSs), modified Rankin scale (mRS) scores, serum malondialdehyde (MDA), superoxide dismutase enzyme (SOD) and glutathione peroxidase (GSH-px) were compared between the 2 groups. Results (1) After treatment, ICP levels at day 7 for the patients in the 2 groups were all significantly higher than ICP levels at day 1 and day 14 (P 0.05). (2) There was statistical significance in the levels of MDA, SOD and GSH-px in the patients of the 2 groups at day 14 after treatment, as compared with those before treatment (P<0.05 or P<0.01). (3) NIHSS scores of the patients in the 2 groups after treatment were significantly lower than those before treatment at day 7, 14 and 21(P<0.01). NIHSS scores of the patients in the observation group at day 7, 14 and 21 after surgery were significantly lower than those in the control group (P<0.05) . (4) Clinical follow-ups after 3 months of treatment indicated that recovery rate of ADL classification of the observation group was obviously higher than that of the control group(P<0.01). (5) Statistical significance could be noted in the scores of mRS and SSS at day 20, 30 and 90 for the patients of the 2 groups, as compared with those before treatment (P<0.05 or P<0.01), and at day 90 after treatment, statistical significance could also be noticed in the scores of mRA and SSS scores, when comparison were made between the patients of the 2 groups (P<0.05). Conclusions Early HBO combined with minimally invasive catheter puncture plus routine therapy could improve neurological functions of the patients with HICH and the quality of daily life. For this reason it was worth further clinical promotion. Key words: Hyperbaric oxygen; Hypertensive intracerebral hemorrhage; Minimally invasive puncture; Hematoma puncture; Drainage; Clinical efficacy