Abstract
BAB amphiphilic triblock copolymers consisting of poly(ethylene glycol) (B)(PEG) as the hydrophilic segment and different polyesters (A) as the hydrophobicblock were prepared by a polycondensation reaction as efficient model core–shellnanoparticles to assay the effect of interactions between the hydrophobic drugand the polyesteric core in terms of drug loading content and release profile.PEG–poly(hexylene adipate)–PEG (PEG–PHA–PEG) and PEG–poly(butyleneadipate)–PEG (PEG–PBA–PEG) to PEG–poly(ethylene adipate)–PEG (PEG–PEA–PEG)core–shell type nanoparticles entrapping quercetin (an anticarcinogenic, allergyinhibitor and antibacterial agent), were prepared by a nanoprecipitation method andcharacterized by dynamic light scattering (DLS), transmission electron microscopy(TEM) and x-ray diffraction (XRD) techniques. It was found that the obtainednanoparticles showed a smooth surface and spherical shape with controllable sizes in therange of 64–74 nm, while drug loading varied from 7.24% to 19% depending onthe copolymer composition and the preparation conditions. The in vitro releasebehaviour exhibited a sustained release and was affected by the polymer–druginteractions. UV studies revealed the presence of hydrogen bonding as the mainexisting interaction between quercetin and polyesters in the nanosphere cores.
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