Abstract
In Dahl S or SHR on high salt diet, activation of NF‐κB contributes to cardiac hypertrophy and renal damage, which may be offset by activation of CREB. The brain RAAS mediates the salt‐induced hypertension, possibly by NF‐κB in the PVN. We assessed effects of high salt diet on DNA‐binding activity of NF‐κB and CREB in the heart, kidney and PVN of WKY rats and SHR on high (8%) or reg (0.6%) salt diet for 2 or 4 weeks (n=6). NF‐κB and CREB DNA binding activity were studied by electrophoretic mobility shift assay.In WKY, high salt only increased CREB DNA binding activity in the LV and NFκB in the PVN. In SHR, high salt increased NF‐κB DNA‐binding activity in the heart and kidney, but decreased CREB binding activity in the heart, kidney, and the PVN.ConclusionHigh salt causes an inverse relationship between NF‐κB and CREB in the LV, kidney and PVN which may contribute to salt induced sympathetic hyperactivity, LV and renal hypertrophy in SHR.
Published Version
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