Effects of High-Dose Vitamin C on Liver Function, Systemic Inflammatory and Immune Responses in Patients with Severe Acute Pancreatitis

Abstract

The objective of this study was to explore the impact of high-dose vitamin C on severe acute pancreatitis patients. This study involved 76 hospital patients from November 2022 to November 2023, divided into two groups: a high-dose group (44 patients) receiving 10 g of vitamin C daily and a routine-dose group (32 patients) receiving 1 g daily. The study evaluated treatment effects, liver function, inflammation levels, and blood T-lymphocyte subsets and complications. At 14 days, the high-dose group showed better overall treatment effects, lower levels of liver enzymes and inflammatory markers, and higher levels of T lymphocytes, with no significant difference in complications compared to the routine-dose group. The findings suggest that high-dose vitamin C effectively improves liver function, reduces inflammation, and boosts immunity in severe acute pancreatitis patients.