Abstract
A technique is described that was used to produce laminar lesions at different depths of the cerebral cortex in rabbits, cats, and monkeys by means of heavy, ionizing particles delivered in a beam from a 60-in. cyclotron. Dosimetric problems are discussed in detail. Examination of 384 radiation lesions indicated that a laminar lesion was produced by peak doses of 15000 to 45000 rads. The corresponding surface and average doses were 3000 to 9000, and 5000 to 15000 rads respectively. A technique of multiple irradiations with a shift of the zone of maximal ionization is described. Some observations pertaining to the latent period of radiation lesions of the brain and data on the relation between the width of the laminar lesion and the magnitude of the radiation dose are presented and discussed. (C.H.)
Published Version
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