Abstract
Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser 7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC 50) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser 7]neurotensin and neurotensin were not significantly different in any tissue studied.
Published Version
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