Abstract
The use of herbicides no matter how diluted it maybe, may have physiological effects on mammals. This work tends to examine the effects dilution factor of 104 of a 10-fold serial dilution of gramoxon herbicide graded into 0.25, 0.5 and 0.75 mg/kg body weight, orally administered to twenty male and twenty female rats has on progesterone, testosterone, albumin and total protein of the rats. The weights of the rats ranges between 79 -119g and were divided randomly into group A, B, C and D. Each group has 10 animals, 5 male and 5 female. Group A is the control. Group A, B.C and D were fed with feed and water ad libitum. Group B, C and D were administered 0.25, 0.5 and 0.75mg/kg bw dose respectively. After 28 days the rats were sacrificed and blood collected into EDTA bottles for laboratory assessment. Computer based ANOVA excel showed that albumin and total protein revealed a significant difference (p<0.05) in group B (0.25mg/kg bw), C (0.5mg/kg bw) and D (0.75mg/kg bw) in both sex compared with control. Testosterone and progesterone level showed a significant decrease (p<0.05) compared with control in group B, C and D. The results clearly indicated that gramoxon herbicide has biochemical and reproductive effects on albino rats even at 10-fold dilution.
Published Version
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