Abstract
Objective: Implantation in the human is dependent upon the invasion of embryonic trophoblasts into the decidua of the maternal endometrium. The regulated expression of uPA and PAI-1 in the human trophoblasts have been shown to mediate key events in human placenta invasion and placentation. To date, the factors capable of regulating the expression of uPA and PAI-1 in placenta remain poorly characterized. In the present study, we have examined the ability of Gonadotropin-Releasing Hormone (GnRH I) and a novel form of Gonadotropin-Releasing Hormone (GnRH II), that are expressed in the human placenta, to regulate uPA and PAI-1 levels in primary cultures of human extravillous cytotrophoblasts (EVT).
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