Effects of goal-oriented liquid therapy on postoperative complications in elderly patients undergoing radical gastrectomy for gastric cancer

Abstract

Objective To analyze effects of target-oriented liquid therapy on postoperative complications in elderly hypertensive patients with radical gastrectomy. Methods 156 elderly patients with hypertension who underwent radical gastrectomy in our hospital from January 2014 to December 2015 were divided into the conventional group and the target group according to a random number table.Routine infusion was given to the patients in the conventional group, while the patients in the target group were treated with intraoperative target-oriented liquid therapy.Intraoperative liquid intake and output volume, hospital stay, vasoactive drug use rate and the incidence of complications within 1 month after surgery were compared between the two groups. Results Target group versus conventional group showed that the colloid volume was(832.3±216.6) ml vs.(1 031.3±245.8) ml, the amount of crystals was(1 157.6±149.2) ml vs.(1 559.8±201.4) ml, the total fluid replenishment was(1 940.2±328.9) ml vs.(2 650.0±276.6) ml, the hospitalization time was(9.8±1.1)d and(12.5±2.0)d(t=-5.607, -13.771, -18.021 and -10.447, respectively, all P=0.000). The use rate of vasoactive drugs was higher in the conventional group〔69.2%(54/78)〕than in the target group〔29.5%(23/78)〕(χ2=24.645, P=0.000). The complications within 1 months after surgery was higher in the conventional group〔12.8%(10/78)〕than in the target group〔3.8%(3/78)〕(χ2=4.112, P=0.043). Conclusions Target-oriented liquid therapy can improve the prognosis of elderly patients receiving radical gastrectomy, reduce the incidence of postoperative complications and promote the early rehabilitation. Key words: Stomach neoplasms; Hypertension; Postoperative complications