Abstract
The effects of glycine (GLY) or (+/-)-3-amino-1-hydroxy-2-pyrrolidone (HA966), a GLY receptor antagonist, microinjections into sites along the rostrocaudal axis of the dorsal periaqueductal gray matter (dPAG) were studied in rats placed on the elevated plus maze (EPM). Selective alterations in the open-arm entries (OAEs) or open-arm time (OAT) of the EPM were the indexes of anxiety. HA966 (30 or 100 nmol, 0.3 microl) increased OAEs and OAT in all 3 dPAG sites, suggesting an anxiolytic effect. GLY (80 and 120 nmol, 0.3 microl) selectively reduced OAEs and OAT, suggesting an anxiogenic effect only when injections were given within the caudal dPAG. When administered together, HA966 reversed the anxiogenic effect of 120 nmol GLY, indicating pharmacological selectivity for the effects of GLY on GLY receptors. Results reinforce an involvement of N-Methyl-D-aspartate-coupled GLY receptors in anxiety and suggest that saturation of this receptor may vary along the dPAG.
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