Abstract
BackgroundGestational diabetes mellitus is a leading medical condition woman encounter during pregnancy with serious short- and long-term consequences for maternal morbidity. However, limited evidence was available on potential impacts of gestational diabetes mellitus using updated international diagnostic criteria on adverse maternal outcomes. Therefore, this study aimed to assess the effects of gestational diabetes mellitus on the risk of adverse maternal outcomes in Northwest Ethiopia.MethodsA prospective cohort study was conducted among pregnant women followed from pregnancy to delivery. Gestational diabetes mellitus status was determined by using a two-hour 75 g oral glucose tolerance test and based on updated international diagnostic criteria. Multivariable log-binomial model was used to examine the effects of gestational diabetes mellitus on the risk of adverse maternal outcomes.ResultsA total of 694 women completed the follow-up and included in the analysis. Women with gestational diabetes mellitus had a higher risk of composite adverse maternal outcome (ARR=1.58, 95% CI: 1.22, 2.04), caesarean delivery (ARR=1.67; 95%: 1.15, 2.44), pregnancy induced hypertension (ARR= 3.32; 95%: 1.55, 7.11), premature rupture of membranes (ARR= 1.83; 95%: 1.02, 3.27), antepartum hemorrhage (ARR= 2.10; 95%: 1.11, 3.98) and postpartum hemorrhage (ARR= 4.85; 95%:2.28, 10.30) compared to women without gestational diabetes mellitus.ConclusionsGestational diabetes mellitus increased the risk of adverse maternal outcomes. This implies that maternal care and intervention strategies relating to women with gestational diabetes mellitus should be strengthened.
Highlights
Gestational diabetes mellitus is a leading medical condition woman encounter during pregnancy with serious short- and long-term consequences for maternal morbidity
Gestational diabetes mellitus has been associated with an increased risk for pregnancy induced hypertension (PIH) with relative risk ranges from 1.4 to 4.15 [4,5,6,7,8,9] some studies suggest that the relation between PIH and GDM is not well understood [10, 11]
Characteristics of participants A total of 1027 women were recruited at the ANC clinic and prospectively followed from pregnancy to delivery
Summary
Gestational diabetes mellitus is a leading medical condition woman encounter during pregnancy with serious short- and long-term consequences for maternal morbidity. Gestational diabetes mellitus has been associated with an increased risk for pregnancy induced hypertension (PIH) with relative risk ranges from 1.4 to 4.15 [4,5,6,7,8,9] some studies suggest that the relation between PIH and GDM is not well understood [10, 11]. It increases the rate of cesarean delivery by up to 57.4% and has a greater impact in cases of obesity and/or previous history of cesarean section [12,13,14,15,16,17,18]. Other studies showed the absence of significant association between
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