Abstract
ObjectivesTo determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a Turkish population.Methods130 smokers and 130 non-smokers were recruited. Individuals who never smoked were described as non-smokers. 130 smokers were treated with nicotine replacement therapy (NRT) (n = 40), bupropion (n = 47), bupropion + NRT (n = 15), and varenicline (n = 28). Smokers were checked by phone after 12 weeks of treatment whether they were able to quit smoking or not. Genotyping and phenotyping were performed.ResultsCessation rates were as follows; 20.0% for NRT, 29.8% for bupropion, 40.0% for bupropion + NRT, 57.1% for varenicline (p = 0.013). The frequency of ABCB1 1236TT-2677TT-3435TT haplotype was significantly higher in non-smokers as compared to smokers (21.5% vs. 10.8, respectively; p = 0.018). Neither smoking status nor smoking cessation rates were associated with genetic variants of CYP2A6 (p = 0.652, p = 0.328, respectively), or variants of CYP2B6 (p = 0.514, p = 0.779, respectively).ConclusionGenetic variants of the drug transporter ABCB1 and the 1236TT-2677TT-3435TT haplotype was significantly associated with non-smoking status. Neither ABCB1 nor CYP2A6, CYP2B6 genetic variants were associated with smoking cessation rates at the 12th week of drug treatment.
Highlights
Tobacco smoking is a major health problem globally
Liver, kidney diseases, anxiety disorder according to DSM V, pregnant women, and subjects using a nicotine product other than cigarettes or those having an addiction other than nicotine were excluded from the study
Our results showed that the genetic polymorphisms of the drug transporter ABCB1 (MDR1) were significantly associated with non-smoking status in a cohort of Turkish subjects
Summary
Tobacco smoking is a major health problem globally. Over one billion people around the world consume tobacco products and an estimated six million people, including children are clinically affected. This number is expected to rise to eight million by the year 2030 (WHO, 2017). Among current first-line pharmacotherapies in smoking cessation are nicotine replacement therapy (NRT), bupropion, and varenicline. The success of smoking cessation treatments may be altered by some pharmacogenetic factors, including genetic variants of drug metabolizing enzymes or drug transporters (Lerman et al, 2006; Benowitz, 2008; Bergen et al, 2013; Chenoweth and Tyndale, 2017)
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