Abstract
The probiotics and prebiotis as microecological modulator have dramatic effects on the microdysbiosis. We found the effects of Ganoderan (GD) in normal flora in intestinal tract of mice. The mice were divided into normal group, decontaminated (DC) group, GD treated group and Bacillus bifidus praeparatum (LZCL) treated group, in which the three groups were treated per os with Lincomycin to be the DC model. After six‐day treatment, the intestinal flora were detected. Lincomycin decreased the number of Bifidobacterium, Bacteroid and Lactobacillus in intestinal tract of mice. The voltatile fatty acid, acetic acid, propionic acid and butanoic acid in blindgut of mice were decreased, suggesting that the dysbacteria were induced in DC mice. After six‐day treatment, the enteric bacilli and enterococcus of GD treatment group and LZCL group were lower than that of DC group, the Bifidobacterium and Bacteroid of GD treatment Group, while LZCL group were higher than that of DC group. The acetic acid, propionic acid and butanoic acid in blindgut of GD treated group and LZCL group were increased. But the level of acetic acid, propionic acid and butanoic acid in blindgut of DC group were lower than that of normal group. The morphologic data showed that the pathological changes of intestinal mucosa restored to normal state after treatment. These results suggest that the GD is an important microecological modulator.
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