Abstract
Slices of rat neostriatum were incubated in Krebs-Henseleit medium. Modulation of [ 3H]GABA release by GABA agonists and antagonists was investigated. The GABA A receptor agonists muscimol (0.1 μM) and isoguvacine (5 μM) enhanced the stimulated release of [ 3H]GABA. The antagonists picrotoxin (1 μM) and bicuculine (50 μM) prevented the effects of the agonists. In the presence of naloxone (1 μM), which blocked the effects of enkephalinergic neurons within the slice preparation, muscimol (1 μM) no longer affected the release of [ 3H]GABA.
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